We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Read More
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
Read More
8
Zinc treatment helps cold sores
Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.
We aimed to understand how zinc might affect the occurrence and duration of cold sores, also known as herpes labialis. In our study, we treated 20 patients, mostly women with an average age of 26.6, who experienced more than six episodes of cold sores each year. They received zinc sulphate at a dose of 22.5 mg twice daily during specific months over a year while we monitored their symptoms for 12 months.
Our results were promising. Patients reported a decrease in the frequency of cold sore episodes, averaging fewer than four instances per year. Moreover, the duration of these episodes was also shortened to around 5.7 days, significantly less than usual for these conditions.
Thus, we can say that systemic zinc sulphate seemed to effectively reduce both the number of cold sore outbreaks and the recovery time. This suggests that zinc might be a beneficial option for individuals who struggle with recurrent cold sores.
Read More
Most Useful Reviews
9
Quick recovery aid
2 people found this helpful
This is an excellent drug for quickly addressing deficiencies or when one is unwell. With a cold, I take it for 5-7 days, and it helps me recover faster. I've recommended it to my family, and they agree on its efficacy.
Read More
10
Preventative effect
I struggled to find zinc that didn't upset my stomach, and this one is perfect. For two years, I haven't had any colds or sick days—it's always there to save me!
Read More
9
Highly effective
This zinc product, with its good dosage and form, is one I often take when I catch a cold. It is remarkably effective.
We explored the connection between zinc levels and recurrent herpes labialis (RHL), commonly known as cold sores. In a study involving 80 individuals, we compared the salivary zinc levels of healthy people with those experiencing RHL during both the acute and convalescent phases.
The findings revealed that patients in the acute phase had significantly lower zinc levels (160.8 ng/ml) compared to when they were recovering (205.7 ng/ml). Both those phases showed lower zinc levels than the healthy individuals' average. This suggests that zinc levels are not just lower when cold sores are present, but also improve after the lesions heal.
Our results indicate that maintaining adequate zinc levels might be beneficial for people suffering from cold sores. Incorporating zinc supplements could play a role in both treating and preventing these uncomfortable outbreaks. We found that increasing serum zinc might help RHL patients, shedding light on a potential supportive treatment strategy for cold sores.
Read More
9
Zinc may relieve cold sores
Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.
We conducted a small pilot study to investigate how a combination of L-lysine, zinc, and herbal ingredients could help treat cold sores caused by the Herpes simplex virus. Our goal was to observe the changes in symptoms such as itching, burning, and soreness among participants over the course of treatment.
Thirty individuals, split evenly between genders, participated in our open-label study. We monitored their symptoms through various methods, including self-reported outcomes, photographs, and daily diaries. By the sixth day of treatment, most participants showed considerable improvement, with some experiencing full resolution of their symptoms.
While we didn't isolate the effect of zinc alone, its inclusion in the treatment mix seems promising. By the end of our study, we found that 87 percent of participants had improved symptomatically, which indicates that the combination treatment may effectively relieve cold sore symptoms. Importantly, no adverse effects were reported during the study, which adds to our understanding of these treatments' safety.
Read More
9
Zinc cream alleviates cold sores
A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Read More
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
Read More
8
Pomegranate extract reduces inflammation
Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin.
We examined how the combination of pomegranate rind extract (PRE) and zinc impacts cold sores, particularly focusing on inflammation. By applying these substances to ex vivo porcine skin, we were able to assess their ability to modulate COX-2, a key player in the inflammation process.
Our findings revealed that the topical application of PRE significantly reduced COX-2 levels in the skin after just six hours and maintained this effect for 24 hours. When we combined PRE with zinc, the results matched those of PRE alone, indicating that zinc didn't add extra benefits to inflammation control when used together.
However, we also noted that zinc alone showed no significant anti-inflammatory effect, highlighting that the benefits we observed were primarily due to the pomegranate extract rather than zinc. This suggests that while zinc is commonly thought beneficial for treating cold sores, its impact on inflammation might be limited unless paired with more potent anti-inflammatory agents like PRE.
In conclusion, pomegranates present a promising approach to managing inflammation and pain associated with cold sores, but zinc’s standalone effectiveness requires reconsideration.
This is an excellent drug for quickly addressing deficiencies or when one is unwell. With a cold, I take it for 5-7 days, and it helps me recover faster. I've recommended it to my family, and they agree on its efficacy.
Read More
10
Preventative effect
I struggled to find zinc that didn't upset my stomach, and this one is perfect. For two years, I haven't had any colds or sick days—it's always there to save me!
Read More
9
Highly effective
This zinc product, with its good dosage and form, is one I often take when I catch a cold. It is remarkably effective.
Read More
9
Great for colds
Excellent! I appreciate that it contains copper too. It works effectively for colds and helps replenish deficiencies.
Read More
9
Balanced formulation
Great dosage with added copper! I've been taking this product for over two years. The balance of copper is just right. Typically, I take 2-3 tablets daily during flu or cold seasons, and it really helps. ^^
Cold sores, also known as fever blisters, are small, fluid-filled blisters that typically appear on or around the lips, although they can also occur in other areas of the face. They are caused by the herpes simplex virus (HSV), primarily HSV-1, and are highly contagious. The initial outbreak may be accompanied by symptoms such as fever, swollen lymph nodes, and a general feeling of malaise. Once infected, the virus remains dormant in the body and can reactivate, leading to recurring outbreaks, often triggered by stress, illness, or exposure to sunlight.
Treatment options for cold sores often focus on alleviating symptoms and speeding up healing. Over-the-counter creams containing antiviral medication like docosanol can help reduce the duration of an outbreak when applied early on. Prescription medications may be recommended for more severe cases. Home remedies, such as applying ice, using aloe vera, or taking lysine supplements, may also offer some relief. Prevention strategies include avoiding known triggers and practicing good hygiene, like not sharing utensils or personal items with infected individuals.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is often touted as a potential remedy for cold sores, primarily due to its immune-boosting properties and its role in skin health. Research suggests that zinc may help reduce the severity and duration of cold sore outbreaks, as it can inhibit the replication of the herpes simplex virus, the virus responsible for cold sores. It is available in various forms, including topical ointments and oral supplements. When applied directly to the affected area, zinc oxide or zinc sulfate creams may help soothe the skin and promote healing.
However, it's important to note that while zinc may aid in managing cold sores, it is not a cure. Results can vary from person to person, and some may find topical treatments to be more effective than others. Always consult a healthcare professional before starting any new treatment regimen, as they can provide guidance tailored to your specific situation. Additionally, maintaining a healthy lifestyle, including proper nutrition and stress management, can further support your immune system in preventing and managing outbreaks effectively.
Based on user reviews, the time it typically takes to see results when taking this supplement for cold sores can vary, but many users report experiencing benefits within a few days to a week of consistent use. For example, one user noted that they take the supplement during bouts of colds for about 5-7 days and find it helps them recover faster Read Review. Another user mentioned that since they began using this supplement regularly, they have noticed improvements in their immune response and have caught colds less frequently Read Review.
Others emphasize the importance of consistent, daily use for optimal effects. For instance, one user indicated that they take the supplement daily during cold seasons and it significantly aids in speeding up recovery Read Review. Overall, while results can be seen fairly quickly, consistent use appears to be key in maximizing the benefits of the supplement for cold sores and overall immune health.
The evidence surrounding the use of zinc supplements for cold sores is mixed, with various studies suggesting potential benefits but also highlighting some limitations. For instance, one study indicated that while zinc levels are generally lower during cold sore outbreaks, supplementation might help decrease recovery times for those with recurrent herpes labialis (cold sores) [1]. Another investigation found that topical applications of zinc sulfate gel not only reduced symptoms but also accelerated healing, making it a promising treatment option [8].
However, it is important to note that zinc's effectiveness might be limited. A study indicated that topical application of zinc did not significantly reduce inflammation associated with cold sores when used alone [2]. Moreover, while zinc in combination with other agents, such as L-lysine, showed potential, the studies did not isolate zinc's impact conclusively [6]. Therefore, while zinc may play a role in managing cold sores, it is best viewed as a supportive treatment rather than a standalone solution, especially in conjunction with more established therapies like antiviral medications to ensure optimal results.
Users have reported a variety of improvements in their symptoms after using the zinc supplement. Many highlight its efficacy in shortening the duration of colds and flu; for instance, one user noted that taking the supplement for 5-7 days during a cold leads to faster recovery Read Review. Another user emphasized that their family has noticed enhanced immunity, experiencing fewer illnesses despite exposure to various cold viruses at kindergarten Read Review. Additionally, multiple reviews indicated a general improvement in immune response and a significant reduction in the frequency of colds after regular use of the supplement Read Review.
Moreover, users appreciate the inclusion of copper alongside zinc, which some believe enhances its effectiveness. One user mentioned that the combination significantly reduces their downtime when catching a cold Read Review. While many reviews are positive, it is essential to note that individual results can vary widely based on factors such as dosage, consistency of use, and personal health conditions.
Users have shared various experiences when it comes to combining this supplement with other products for managing cold sores and overall health. Many users highlighted the benefits of taking zinc alongside copper, as they believe this combination enhances immunity and effectiveness, particularly during cold and flu season. For example, one user indicated that the inclusion of copper in the supplement significantly reduces their downtime when they catch a cold Read Review. Others have mentioned that they take the supplement in conjunction with vitamins and magnesium for a synergistic effect, contributing positively to their recovery from various ailments Read Review.
Additionally, users have reported positive outcomes combining zinc with other dietary supplements to bolster their immune response during cold seasons. For instance, one reviewer noted they use zinc with other supplements for prevention, resulting in no colds during autumn and winter Read Review. Moreover, consistent use of zinc is emphasized across various reviews, with many users recommending it as part of a daily regimen to enhance immunity and reduce the frequency of illnesses Read Review. Overall, the integration of this zinc supplement with other products appears to be a common strategy among users seeking to manage their health effectively.
Research indicates that zinc may hold promise as a supportive treatment for cold sores. One significant study utilized zinc sulfate at a dose of 22.5 mg taken twice daily, revealing that participants experienced a reduction in both the frequency and duration of outbreaks (averaging fewer than four episodes per year with an average recovery time of 5.7 days) [5]. This suggests that maintaining adequate zinc levels through supplementation could be beneficial for individuals frequently suffering from cold sores.
In addition to oral supplementation, topical formulations such as zinc oxide and zinc sulfate gel have demonstrated effectiveness in clinical trials. Participants using zinc oxide/glycine cream within the first 24 hours of symptoms reported shorter healing times, averaging about 5 days, compared to 6.5 days for those using a placebo [7]. Moreover, research shows that low concentrations of zinc sulfate can prevent outbreaks when applied topically, indicating its potential as a preventive measure [9]. Therefore, while zinc alone may not be a standalone cure, its incorporation into treatment protocols—both orally and topically—should be considered for those prone to cold sores.
9
Quick recovery aid
2 people found this helpful
This is an excellent drug for quickly addressing deficiencies or when one is unwell. With a cold, I take it for 5-7 days, and it helps me recover faster. I've recommended it to my family, and they agree on its efficacy.
7.5
Reduces colds
For cold prevention, zinc is reputed to be beneficial, and I've noticed that since I began taking it, I've caught colds less frequently. The product is small, tasteless, and odourless, making it easy to consume. It seems to be high-quality zinc.
7.5
Accelerates recovery
I always rely on OptiZinc during bouts of colds and viral infections. It significantly aids in speeding up recovery. However, it's advisable not to use it for more than two weeks consecutively.
9
Strengthens immunity
1 people found this helpful
If only you knew the power of OptiZinc! I take one tablet daily and have noticed significant changes: my immunity has improved remarkably. My child attends kindergarten and often brings home various cold viruses. However, since everyone in the family began taking this supplement, our immune systems have been bolstered, and we have not fallen ill during the epidemic. I wholeheartedly give this product five stars! 💪🔥
7.5
Reduces inactivity
1 people found this helpful
Optizinc, the most assimilated zinc formula, includes copper, boosting my immunity. When I catch a flu or a cold, I take one pill daily, significantly reducing my downtime.
0
No effect noted
13 people found this helpful
Copper can be taken alongside zinc, which was prescribed to me by an otolaryngologist for a sore in my mouth. I was given zinc for only two weeks, costing around 7,000 yen monthly, yet it had no effect. Despite taking 2 capsules, my mouth remains sore. I believe there is a synergistic effect from the vitamins and magnesium I’m taking. While prescription drugs may be more effective, I'm inclined to find something suitable that is also affordable.
9
Effective in prevention
1 people found this helpful
Zinc is readily available and balanced with copper. I bought it to take in combination with others for prevention during autumn and winter. I had no allergic reactions, just slight nausea from taking it on an empty stomach, so I now take it after meals. Fortunately, I have not had any colds while using these supplements, which indicates they are effective.
7
Zinc and cold sore recovery
Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals.
We explored the relationship between zinc levels and recurrent herpes labialis (cold sores) through a study involving 43 patients with a history of this condition and 42 healthy individuals. By measuring serum zinc levels using a colorimetric method, we aimed to find out whether these levels differ significantly between both groups and how they relate to the severity and duration of cold sore episodes.
Although we found that serum zinc levels did not significantly differ between the patients and healthy subjects, we observed an interesting correlation regarding recovery times. Specifically, lower serum zinc levels appeared to be linked to longer recovery periods from cold sores. This suggests that zinc might play a role in speeding up recovery, though it was not a significant factor influencing relapse frequency or patient demographics such as age and sex.
Overall, while the study didn’t establish a direct benefit of zinc supplementation, the findings indicate that zinc deficiency might contribute to longer-lasting cold sores. Therefore, we suggest that evaluating zinc levels in patients experiencing recurrent cold sores could be beneficial and that zinc supplementation may be worth considering in treatment protocols.
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
8
Pomegranate extract reduces inflammation
Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin.
We examined how the combination of pomegranate rind extract (PRE) and zinc impacts cold sores, particularly focusing on inflammation. By applying these substances to ex vivo porcine skin, we were able to assess their ability to modulate COX-2, a key player in the inflammation process.
Our findings revealed that the topical application of PRE significantly reduced COX-2 levels in the skin after just six hours and maintained this effect for 24 hours. When we combined PRE with zinc, the results matched those of PRE alone, indicating that zinc didn't add extra benefits to inflammation control when used together.
However, we also noted that zinc alone showed no significant anti-inflammatory effect, highlighting that the benefits we observed were primarily due to the pomegranate extract rather than zinc. This suggests that while zinc is commonly thought beneficial for treating cold sores, its impact on inflammation might be limited unless paired with more potent anti-inflammatory agents like PRE.
In conclusion, pomegranates present a promising approach to managing inflammation and pain associated with cold sores, but zinc’s standalone effectiveness requires reconsideration.
9
Zinc may relieve cold sores
Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.
We conducted a small pilot study to investigate how a combination of L-lysine, zinc, and herbal ingredients could help treat cold sores caused by the Herpes simplex virus. Our goal was to observe the changes in symptoms such as itching, burning, and soreness among participants over the course of treatment.
Thirty individuals, split evenly between genders, participated in our open-label study. We monitored their symptoms through various methods, including self-reported outcomes, photographs, and daily diaries. By the sixth day of treatment, most participants showed considerable improvement, with some experiencing full resolution of their symptoms.
While we didn't isolate the effect of zinc alone, its inclusion in the treatment mix seems promising. By the end of our study, we found that 87 percent of participants had improved symptomatically, which indicates that the combination treatment may effectively relieve cold sore symptoms. Importantly, no adverse effects were reported during the study, which adds to our understanding of these treatments' safety.
8
Zinc treatment helps cold sores
Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.
We aimed to understand how zinc might affect the occurrence and duration of cold sores, also known as herpes labialis. In our study, we treated 20 patients, mostly women with an average age of 26.6, who experienced more than six episodes of cold sores each year. They received zinc sulphate at a dose of 22.5 mg twice daily during specific months over a year while we monitored their symptoms for 12 months.
Our results were promising. Patients reported a decrease in the frequency of cold sore episodes, averaging fewer than four instances per year. Moreover, the duration of these episodes was also shortened to around 5.7 days, significantly less than usual for these conditions.
Thus, we can say that systemic zinc sulphate seemed to effectively reduce both the number of cold sore outbreaks and the recovery time. This suggests that zinc might be a beneficial option for individuals who struggle with recurrent cold sores.
9
Zinc cream alleviates cold sores
A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
8
Zinc effective for cold sores
Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution.
We explored the effectiveness of low concentrations of zinc sulphate solution in managing recurrent cold sores. The study documented that applying zinc sulphate directly to the skin or oral mucous membrane showed promising results in preventing outbreaks of herpes simplex virus, which causes cold sores.
Specifically, we noted that a solution concentration of 0.025-0.05% for the skin and 0.01-0.025% for the oral area was used for treatment. Not only did this approach seem beneficial for active infections, but it also aided in stopping the recurrence of post-herpetic erythema multiforme—a condition related to past herpes outbreaks.
Overall, these findings are exciting for anyone struggling with the recurring pain and embarrassment of cold sores, as they suggest a relatively simple topical treatment could help reduce flare-ups. We believe this research paves the way for further discussions about using zinc sulphate as a viable option for managing such conditions effectively.
References
Ranjbar Z, Zahed M, Ranjbar MA, Shirmardan Z. Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals. BMC Oral Health. 2020;20:296. 10.1186/s12903-020-01277-2
Houston DM, Bugert J, Denyer SP, Heard CM. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin. Eur J Pharm Biopharm. 2017;112:30. 10.1016/j.ejpb.2016.11.014
Khozeimeh F, Jafari N, Attar AM, Jafari S, Ataie M. Comparative analysis of salivary zinc level in recurrent herpes labialis. Dent Res J (Isfahan). 2012;9:19. 10.4103/1735-3327.92922
Opstelten W, Neven AK, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician. 2008;54:1683.
Femiano F, Gombos F, Scully C. Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy. J Oral Pathol Med. 2005;34:423.
Singh BB, Udani J, Vinjamury SP, Der-Martirosian C, Gandhi S, et al. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev. 2005;10:123.
Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.
Kneist W, Hempel B, Borelli S. [Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans]. Arzneimittelforschung. 1995;45:624.
Brody I. Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution. Br J Dermatol. 1981;104:191.